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Copying pasting from two previous posts... As power increases, car manufacturers make the gears longer and not shorter as leader gears do (look at Z06, ZTT vs ZNA, etc.). With leader gears and even a mildly modified TT, you'll be spinning tires in first and second, and will not be using the lower gears completely because you'll have to short-shift. To further clarify, consider the first gear (or even the second). If you're at 400RWHP+, you'll be limited by the tire traction not the torque so leader gears or not you'll have the same acceleration. Leader gears, on the other hand, will require you to shift at lower speeds and the cruising RPM will increase by 10% which can be an issue. So the obvious disadvantage is lower mileage. Also, if you're trapping between 96mph and 107mph in the quarter mile, leader gears would require an additional (time consuming) shift from the third to fourth that is not required by stock gearing. The car would feel snappier with leader gears but it would not be any faster. 
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